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HMGCL and HSD17B10
Data Source:
BioGRID
(two hybrid)
HMGCL
HSD17B10
Description
3-hydroxy-3-methylglutaryl-CoA lyase
hydroxysteroid 17-beta dehydrogenase 10
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Peroxisome
Peroxisomal Matrix
Cytosol
Protein-containing Complex
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
Molecular Function
Fatty-acyl-CoA Binding
Magnesium Ion Binding
Hydroxymethylglutaryl-CoA Lyase Activity
Structural Molecule Activity
Manganese Ion Binding
Carboxylic Acid Binding
Metal Ion Binding
TRNA Binding
RNA Binding
3-hydroxyacyl-CoA Dehydrogenase Activity
Protein Binding
Cholate 7-alpha-dehydrogenase Activity
Testosterone Dehydrogenase [NAD(P)] Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Biological Process
Liver Development
Leucine Catabolic Process
Protein Targeting To Peroxisome
Lipid Metabolic Process
Acyl-CoA Metabolic Process
Mitochondrion Organization
Response To Nutrient
Response To Starvation
Ketone Body Biosynthetic Process
Response To Fatty Acid
Isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Branched-chain Amino Acid Catabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA Processing
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Pathways
Synthesis of Ketone Bodies
Peroxisomal protein import
Peroxisomal protein import
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
Drugs
3-hydroxyglutaric acid
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
Diseases
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
High light scatter reticulocyte count (
27863252
)
Immature fraction of reticulocytes (
27863252
)
Red blood cell count (
32888494
)
Reticulocyte fraction of red cells (
27863252
)
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Interacting Genes
9 interacting genes:
ADAMTS10
ARL6IP1
DNAJA1
GTF2B
HES1
HSD17B10
MS4A7
PEX5
RNF126
32 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHA1
PDHB
PDHX
PRKN
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
Entrez ID
3155
3028
HPRD ID
02003
02223
Ensembl ID
ENSG00000117305
ENSG00000072506
Uniprot IDs
P35914
A0A0S2Z410
Q99714
PDB IDs
2CW6
3MP3
3MP4
3MP5
1F67
1SO8
1U7T
2O23
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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