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HSD17B10 and HMGCL
Data Source:
BioGRID
(two hybrid)
HSD17B10
HMGCL
Description
hydroxysteroid 17-beta dehydrogenase 10
3-hydroxy-3-methylglutaryl-CoA lyase
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
Mitochondrion
Mitochondrial Matrix
Peroxisome
Peroxisomal Matrix
Cytosol
Protein-containing Complex
Molecular Function
TRNA Binding
RNA Binding
3-hydroxyacyl-CoA Dehydrogenase Activity
Protein Binding
Cholate 7-alpha-dehydrogenase Activity
Testosterone Dehydrogenase [NAD(P)] Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Fatty-acyl-CoA Binding
Magnesium Ion Binding
Hydroxymethylglutaryl-CoA Lyase Activity
Structural Molecule Activity
Manganese Ion Binding
Carboxylic Acid Binding
Metal Ion Binding
Biological Process
Isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Branched-chain Amino Acid Catabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA Processing
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Liver Development
Leucine Catabolic Process
Protein Targeting To Peroxisome
Lipid Metabolic Process
Acyl-CoA Metabolic Process
Mitochondrion Organization
Response To Nutrient
Response To Starvation
Ketone Body Biosynthetic Process
Response To Fatty Acid
Pathways
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
Synthesis of Ketone Bodies
Peroxisomal protein import
Peroxisomal protein import
Drugs
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
3-hydroxyglutaric acid
Diseases
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
High light scatter reticulocyte count (
27863252
)
Immature fraction of reticulocytes (
27863252
)
Red blood cell count (
32888494
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
32 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHA1
PDHB
PDHX
PRKN
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
9 interacting genes:
ADAMTS10
ARL6IP1
DNAJA1
GTF2B
HES1
HSD17B10
MS4A7
PEX5
RNF126
Entrez ID
3028
3155
HPRD ID
02223
02003
Ensembl ID
ENSG00000072506
ENSG00000117305
Uniprot IDs
A0A0S2Z410
Q99714
P35914
PDB IDs
1F67
1SO8
1U7T
2O23
2CW6
3MP3
3MP4
3MP5
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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