HSD17B10 and CS

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		HSD17B10	CS
Description		hydroxysteroid 17-beta dehydrogenase 10	citrate synthase
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Nucleus Mitochondrion Mitochondrial Matrix Extracellular Exosome
	Molecular Function	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	RNA Binding Citrate (Si)-synthase Activity
	Biological Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Carbohydrate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion	Mitochondrial protein import Citric acid cycle (TCA cycle)
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids	Trifluoroacetonyl coenzyme A Coenzyme A Oxaloacetate Ion alpha-Fluoro-carboxymethyldethia coenzyme A complex D-Malic acid Nitromethyldethia coenzyme A Citric acid
Diseases		2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)	Height ( 31562340 23456168) Inflammatory skin disease ( 25574825) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	7 interacting genes: CRYAA CRYAB DYNLL1 HSD17B10 HSPB1 LINC01554 MDH2
Entrez ID		3028	1431
HPRD ID		02223	00349
Ensembl ID		ENSG00000072506	ENSG00000062485
Uniprot IDs		A0A0S2Z410 Q99714	A0A024RB75 O75390
PDB IDs		1F67 1SO8 1U7T 2O23	5UZP 5UZQ 5UZR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?