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HMGCL and DNAJA1
Data Source:
BioGRID
(two hybrid)
HMGCL
DNAJA1
Description
3-hydroxy-3-methylglutaryl-CoA lyase
DnaJ heat shock protein family (Hsp40) member A1
Image
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Peroxisome
Peroxisomal Matrix
Cytosol
Protein-containing Complex
Nucleus
Mitochondrion
Cytosol
Microtubule Cytoskeleton
Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Molecular Function
Fatty-acyl-CoA Binding
Magnesium Ion Binding
Hydroxymethylglutaryl-CoA Lyase Activity
Structural Molecule Activity
Manganese Ion Binding
Carboxylic Acid Binding
Metal Ion Binding
G Protein-coupled Receptor Binding
ATPase Activator Activity
Protein Binding
ATP Binding
Hsp70 Protein Binding
Tat Protein Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Low-density Lipoprotein Particle Receptor Binding
Unfolded Protein Binding
Chaperone Binding
C3HC4-type RING Finger Domain Binding
Biological Process
Liver Development
Leucine Catabolic Process
Protein Targeting To Peroxisome
Lipid Metabolic Process
Acyl-CoA Metabolic Process
Mitochondrion Organization
Response To Nutrient
Response To Starvation
Ketone Body Biosynthetic Process
Response To Fatty Acid
Protein Folding
Response To Unfolded Protein
Spermatogenesis
Response To Heat
Flagellated Sperm Motility
Androgen Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of ATPase Activity
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of JUN Kinase Activity
Regulation Of Protein Transport
Protein Localization To Mitochondrion
Toxin Transport
Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways
Synthesis of Ketone Bodies
Peroxisomal protein import
Peroxisomal protein import
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Drugs
3-hydroxyglutaric acid
Diseases
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS
High light scatter reticulocyte count (
27863252
)
Immature fraction of reticulocytes (
27863252
)
Red blood cell count (
32888494
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
9 interacting genes:
ADAMTS10
ARL6IP1
DNAJA1
GTF2B
HES1
HSD17B10
MS4A7
PEX5
RNF126
24 interacting genes:
ARL4D
BCS1L
BRCA1
CAV2
CD58
CDC16
CFTR
ERG
FZR1
HIVEP1
HMGCL
HSPA8
LINC01554
LSM2
NELFCD
NUDT3
PAXIP1
PGR
PTEN
PTTG1
SUMO2
SUMO4
TM4SF1
TXN
Entrez ID
3155
3301
HPRD ID
02003
04159
Ensembl ID
ENSG00000117305
ENSG00000086061
Uniprot IDs
P35914
B7Z5C0
P31689
PDB IDs
2CW6
3MP3
3MP4
3MP5
2LO1
2M6Y
6E8M
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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