HMGCL

Description		3-hydroxy-3-methylglutaryl-CoA lyase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding
	Biological Process	Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid
Pathways		Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs		3-hydroxyglutaric acid
Diseases		3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Novel Interacting Genes		1 novel interacting genes: SMARCA4
Interacting Genes		9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126
Entrez ID		3155
HPRD ID		02003
Ensembl ID		ENSG00000117305
Uniprot IDs		P35914
PDB IDs		2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
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