HSD17B10 and TOMM22

Data Source:
BioGRID (fluorescent resonance energy transfer)

		HSD17B10	TOMM22
Description		hydroxysteroid 17-beta dehydrogenase 10	translocase of outer mitochondrial membrane 22
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Mitochondrion Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Integral Component Of Membrane
	Molecular Function	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Protein Binding Protein Transmembrane Transporter Activity
	Biological Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Protein Targeting To Mitochondrion Macroautophagy Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Outer Membrane Protein Transmembrane Transport
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases		2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)	C-reactive protein levels ( 30388399) Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	5 interacting genes: AQP6 HSD17B10 KRTAP5-9 TOMM20 TOMM7
Entrez ID		3028	56993
HPRD ID		02223	06130
Ensembl ID		ENSG00000072506	ENSG00000100216
Uniprot IDs		A0A0S2Z410 Q99714	Q549C5 Q9NS69
PDB IDs		1F67 1SO8 1U7T 2O23	7CK6
Enriched GO Terms of Interacting Partners?
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