HSD17B10 and HMGCS2

Data Source:
BioGRID (two hybrid)

		HSD17B10	HMGCS2
Description		hydroxysteroid 17-beta dehydrogenase 10	3-hydroxy-3-methylglutaryl-CoA synthase 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Plasma Membrane Mitochondrial Ribonuclease P Complex Mitochondrial Nucleoid	Mitochondrion Mitochondrial Matrix
	Molecular Function	TRNA Binding RNA Binding 3-hydroxyacyl-CoA Dehydrogenase Activity Protein Binding Cholate 7-alpha-dehydrogenase Activity Testosterone Dehydrogenase [NAD(P)] Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity	Hydroxymethylglutaryl-CoA Synthase Activity Identical Protein Binding
	Biological Process	Isoleucine Catabolic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Bile Acid Biosynthetic Process Mitochondrion Organization C21-steroid Hormone Metabolic Process Androgen Metabolic Process Estrogen Metabolic Process Branched-chain Amino Acid Catabolic Process Protein Homotetramerization Brexanolone Metabolic Process Mitochondrial TRNA Methylation Mitochondrial TRNA Processing Mitochondrial TRNA 5'-end Processing Mitochondrial TRNA 3'-end Processing	Acetyl-CoA Metabolic Process Cholesterol Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Regulation Of Lipid Metabolic Process Ketone Body Biosynthetic Process
Pathways		tRNA processing in the mitochondrion tRNA modification in the mitochondrion Branched-chain amino acid catabolism rRNA processing in the mitochondrion	PPARA activates gene expression Synthesis of Ketone Bodies
Drugs		NADH 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct Omega-3-carboxylic acids
Diseases		2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency Non-syndromic X-linked mental retardation Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)	HMG-CoA synthase (HMGCS) deficiency
GWAS		Bipolar disorder ( 31043756) Body mass index ( 28892062)	Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524) Metabolite levels ( 23823483)
Interacting Genes		32 interacting genes: ALDH3B1 ALDOA APP ATP5F1A CDC42 CHD3 CPS1 CS ETFDH FAF1 GLUD1 GLUL HADHA HADHB HMGCL HMGCS2 HTRA2 MDH1 OGDH PDHA1 PDHB PDHX PRKN PTEN PYGL TOMM20 TOMM22 TOMM40 TRAF3IP2 TRAF5 TRAF6 UBE2D1	3 interacting genes: APP FBXO7 HSD17B10
Entrez ID		3028	3158
HPRD ID		02223	02580
Ensembl ID		ENSG00000072506	ENSG00000134240
Uniprot IDs		A0A0S2Z410 Q99714	A0A140VJL2 P54868
PDB IDs		1F67 1SO8 1U7T 2O23	2WYA
Enriched GO Terms of Interacting Partners?
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