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HMGCL and ARL6IP1
Data Source:
BioGRID
(two hybrid)
HMGCL
ARL6IP1
Description
3-hydroxy-3-methylglutaryl-CoA lyase
ADP ribosylation factor like GTPase 6 interacting protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Mitochondrial Matrix
Peroxisome
Peroxisomal Matrix
Cytosol
Protein-containing Complex
Sec61 Translocon Complex
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Molecular Function
Fatty-acyl-CoA Binding
Magnesium Ion Binding
Hydroxymethylglutaryl-CoA Lyase Activity
Structural Molecule Activity
Manganese Ion Binding
Carboxylic Acid Binding
Metal Ion Binding
Protein Binding
Identical Protein Binding
Biological Process
Liver Development
Leucine Catabolic Process
Protein Targeting To Peroxisome
Lipid Metabolic Process
Acyl-CoA Metabolic Process
Mitochondrion Organization
Response To Nutrient
Response To Starvation
Ketone Body Biosynthetic Process
Response To Fatty Acid
Positive Regulation Of L-glutamate Import Across Plasma Membrane
Cotranslational Protein Targeting To Membrane
Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Endoplasmic Reticulum Tubular Network Formation
Regulation Of Endoplasmic Reticulum Tubular Network Organization
Endoplasmic Reticulum Tubular Network Membrane Organization
Pathways
Synthesis of Ketone Bodies
Peroxisomal protein import
Peroxisomal protein import
Drugs
3-hydroxyglutaric acid
Diseases
3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS
High light scatter reticulocyte count (
27863252
)
Immature fraction of reticulocytes (
27863252
)
Red blood cell count (
32888494
)
Reticulocyte fraction of red cells (
27863252
)
Refractive error (
32231278
)
Interacting Genes
9 interacting genes:
ADAMTS10
ARL6IP1
DNAJA1
GTF2B
HES1
HSD17B10
MS4A7
PEX5
RNF126
77 interacting genes:
ACSF2
AQP6
ARL4D
ARL6
C19orf18
CERT1
DIABLO
EHD3
EMP1
F2RL1
FBXW7
FDFT1
FXR2
GAD2
GAS8
GOLPH3
GOLPH3L
GORASP2
GPR151
GPR152
HGS
HMGCL
HSD17B13
INPP5K
LMNA
MCEMP1
MFSD14B
MFSD5
MGST3
MIEF2
MTERF3
MYG1
NAPB
NDRG4
NTAQ1
NUDT3
PAM16
PBX3
PICK1
PTPN9
RAB33A
REEP6
RETREG3
RNF5
SDCBP
SENP2
SHISA5
SHMT2
SLC10A6
SLC13A1
SLC35C2
SNX1
SNX10
SNX11
SNX12
SNX15
SNX2
SNX3
SNX4
SNX8
SPG21
STARD4
SUCLA2
TARS2
TFAM
TMED8
TMEM14B
TMEM248
TMEM258
TUFM
UBE2I
VMA21
WDFY2
WIPI2
YIPF4
ZFYVE21
ZNF391
Entrez ID
3155
23204
HPRD ID
02003
09641
Ensembl ID
ENSG00000117305
ENSG00000170540
Uniprot IDs
P35914
A0A024QYV7
Q15041
PDB IDs
2CW6
3MP3
3MP4
3MP5
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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