HMGCL and MS4A7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HMGCL	MS4A7
Description		3-hydroxy-3-methylglutaryl-CoA lyase	membrane spanning 4-domains A7
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex	Trans-Golgi Network Integral Component Of Membrane
	Molecular Function	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding	Protein Binding
	Biological Process	Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid
Pathways		Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs		3-hydroxyglutaric acid
Diseases		3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS		High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126	10 interacting genes: CD72 DRAM1 EMP1 HMGCL IGFBP5 ITGB2 LAT PLN PMP22 SLC35F6
Entrez ID		3155	58475
HPRD ID		02003	07579
Ensembl ID		ENSG00000117305	ENSG00000166927
Uniprot IDs		P35914	A0A024R505 A0A024R556 Q9GZW8
PDB IDs		2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
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