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HSD17B10 and CHD3
Data Source:
BioGRID
(two hybrid)
HSD17B10
CHD3
Description
hydroxysteroid 17-beta dehydrogenase 10
chromodomain helicase DNA binding protein 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Plasma Membrane
Mitochondrial Ribonuclease P Complex
Mitochondrial Nucleoid
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
NuRD Complex
PML Body
Centriolar Satellite
Molecular Function
TRNA Binding
RNA Binding
3-hydroxyacyl-CoA Dehydrogenase Activity
Protein Binding
Cholate 7-alpha-dehydrogenase Activity
Testosterone Dehydrogenase [NAD(P)] Activity
17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity
3-hydroxy-2-methylbutyryl-CoA Dehydrogenase Activity
Testosterone Dehydrogenase (NAD+) Activity
Androstan-3-alpha,17-beta-diol Dehydrogenase Activity
Chenodeoxycholate 7-alpha-dehydrogenase (NAD+) Activity
Isoursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Ursodeoxycholate 7-beta-dehydrogenase (NAD+) Activity
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
ATPase Activity
Double-stranded DNA Helicase Activity
Nucleosome-dependent ATPase Activity
Biological Process
Isoleucine Catabolic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Bile Acid Biosynthetic Process
Mitochondrion Organization
C21-steroid Hormone Metabolic Process
Androgen Metabolic Process
Estrogen Metabolic Process
Branched-chain Amino Acid Catabolic Process
Protein Homotetramerization
Brexanolone Metabolic Process
Mitochondrial TRNA Methylation
Mitochondrial TRNA Processing
Mitochondrial TRNA 5'-end Processing
Mitochondrial TRNA 3'-end Processing
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Assembly Or Disassembly
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Spindle Organization
Centrosome Cycle
DNA Duplex Unwinding
ATP-dependent Chromatin Remodeling
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
tRNA processing in the mitochondrion
tRNA modification in the mitochondrion
Branched-chain amino acid catabolism
rRNA processing in the mitochondrion
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Drugs
NADH
1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
Omega-3-carboxylic acids
Diseases
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
Non-syndromic X-linked mental retardation
Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS
Bipolar disorder (
31043756
)
Body mass index (
28892062
)
Ischemic stroke (
26089329
)
Macular thickness (
30535121
)
Prostate cancer (
29892016
)
Refractive error (
32231278
)
Stroke (
26089329
)
Interacting Genes
32 interacting genes:
ALDH3B1
ALDOA
APP
ATP5F1A
CDC42
CHD3
CPS1
CS
ETFDH
FAF1
GLUD1
GLUL
HADHA
HADHB
HMGCL
HMGCS2
HTRA2
MDH1
OGDH
PDHA1
PDHB
PDHX
PRKN
PTEN
PYGL
TOMM20
TOMM22
TOMM40
TRAF3IP2
TRAF5
TRAF6
UBE2D1
96 interacting genes:
ACTR1B
ADH5
AIMP2
ATP5IF1
BARD1
BCL6
BHLHE40
C4orf17
CASP6
CASP8
CPE
CRCT1
CREB1
CREBBP
CSTF2
CTBP1
CTTN
ENTR1
FABP4
FBP2
FUBP1
GADD45A
GIT1
GPS2
GSK3B
H3C1
HABP4
HSD17B10
HSPH1
HTT
IK
IKZF1
IKZF3
IMMT
IVNS1ABP
KIF15
KPNA2
KPNB1
LRIF1
LUC7L2
MAFG
MAN2A2
MX1
MYB
NEFL
NR1H2
NR4A1
PAICS
PCMT1
PIAS4
PLK4
PRG2
PRPF40A
PSME1
PTN
PTPRS
PUF60
RAD51
RETREG2
RGS2
RIF1
RPL29
SAFB
SAT1
SATB1
SERBP1
SERF2
SGSM2
SIRT6
SKIL
SLC27A6
SPOP
SRRT
SUMO1
SUMO2
TAL1
TCERG1
THOC7
TNFRSF14
TNNT1
TP53
TP73
TRIM28
TRIM54
TSC22D1
TSPAN6
TTR
TXNDC9
UBA3
UBC
UBE2I
UROD
VIM
XRCC4
YAE1
ZHX1
Entrez ID
3028
1107
HPRD ID
02223
09071
Ensembl ID
ENSG00000072506
ENSG00000170004
Uniprot IDs
A0A0S2Z410
Q99714
B3KWV4
Q12873
Q2TAZ1
PDB IDs
1F67
1SO8
1U7T
2O23
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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