VDAC1 and DYNLT1

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		VDAC1	DYNLT1
Description		voltage dependent anion channel 1	dynein light chain Tctex-type 1
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Synaptic Vesicle Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Extracellular Exosome	Extracellular Region Mitochondrion Golgi Apparatus Spindle Cytoplasmic Dynein Complex Cytoplasmic Microtubule Lamellipodium Secretory Granule Lumen Neuronal Cell Body Host Cell Axonal Growth Cone Secretory Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Voltage-gated Anion Channel Activity Porin Activity Cholesterol Binding Protein Kinase Binding Phosphatidylcholine Binding Identical Protein Binding Ion Channel Binding Protein-containing Complex Binding Ceramide Binding	Motor Activity Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Behavioral Fear Response Pyruvate Metabolic Process Anion Transport Mitochondrial Calcium Ion Transmembrane Transport Apoptotic Process Neuron-neuron Synaptic Transmission Learning Inorganic Anion Transport Viral Process Macroautophagy Epithelial Cell Differentiation Negative Regulation Of Apoptotic Process Anion Transmembrane Transport Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process	Establishment Of Mitotic Spindle Orientation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Dendrite Development Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Regulation Of GTPase Activity Neutrophil Degranulation Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axon Development Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport	Neutrophil degranulation
Drugs		Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DUX4 DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PLAT PPIF PRKCE PRKN RAF1 RNF31 SUMO4 TOMM20 TUBA4A	50 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 DYNLT2B DYNLT3 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2
Entrez ID		7416	6993
HPRD ID		05137	15987
Ensembl ID		ENSG00000213585	ENSG00000146425
Uniprot IDs		A0A1L1UHR1 B3KTS5 P21796	P63172
PDB IDs		2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73 6TIQ 6TIR	5JPW
Enriched GO Terms of Interacting Partners?
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