VDAC1 and CKMT1B

Data Source:
HPRD (in vitro)

		VDAC1	CKMT1B
Description		voltage dependent anion channel 1	creatine kinase, mitochondrial 1B
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GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Synaptic Vesicle Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Voltage-gated Anion Channel Activity Porin Activity Cholesterol Binding Protein Kinase Binding Phosphatidylcholine Binding Identical Protein Binding Ion Channel Binding Protein-containing Complex Binding Ceramide Binding	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Behavioral Fear Response Pyruvate Metabolic Process Anion Transport Mitochondrial Calcium Ion Transmembrane Transport Apoptotic Process Neuron-neuron Synaptic Transmission Learning Inorganic Anion Transport Viral Process Macroautophagy Epithelial Cell Differentiation Negative Regulation Of Apoptotic Process Anion Transmembrane Transport Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process
Pathways		Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport	Creatine metabolism
Drugs		Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols	Creatine Phosphocreatine
Diseases
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DUX4 DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PLAT PPIF PRKCE PRKN RAF1 RNF31 SUMO4 TOMM20 TUBA4A	13 interacting genes: ASB9 CALM1 CKM CTNNA3 HPCA NUTF2 OCM PPP1R16A PSMC3 RXRG SFRP4 SLC25A5 VDAC1
Entrez ID		7416	1159
HPRD ID		05137	00424
Ensembl ID		ENSG00000213585	ENSG00000237289
Uniprot IDs		A0A1L1UHR1 B3KTS5 P21796	P12532
PDB IDs		2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73 6TIQ 6TIR	1QK1
Enriched GO Terms of Interacting Partners?
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