VCL and LPXN

Data Source:
BioGRID (two hybrid, two hybrid)

		VCL	LPXN
Description		vinculin	leupaxin
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Costamere Cell-cell Contact Zone Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding	Transcription Coregulator Activity Protein Binding Metal Ion Binding
	Biological Process	Morphogenesis Of An Epithelium Platelet Degranulation Muscle Contraction Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Neutrophil Degranulation Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction	Regulation Of Transcription, DNA-templated Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly
Pathways		Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)	Inflammatory bowel disease ( 23128233) Lymphoma ( 23349640) Pulse pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP	33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426
Entrez ID		7414	9404
HPRD ID		01900	05651
Ensembl ID		ENSG00000035403	ENSG00000110031
Uniprot IDs		A0A024QZN4 B3KXA2 P18206 V9HWK2	B7Z5P7 O60711
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW	1X3H 4XEF 4XEK 4XEV
Enriched GO Terms of Interacting Partners?
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