VCL and CLTC

Data Source:
HPRD (in vitro)

		VCL	CLTC
Description		vinculin	clathrin heavy chain
Image
GO Annotations	Cellular Component	Podosome Extracellular Region Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Costamere Cell-cell Contact Zone Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen	Lysosome Endosome Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Endolysosome Membrane Melanosome Clathrin-coated Endocytic Vesicle Extracellular Exosome Clathrin Complex Mitotic Spindle Extracellular Vesicle Mitotic Spindle Microtubule
	Molecular Function	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding	RNA Binding Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding Ubiquitin-specific Protease Binding
	Biological Process	Morphogenesis Of An Epithelium Platelet Degranulation Muscle Contraction Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Neutrophil Degranulation Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction	Mitotic Cell Cycle Osteoblast Differentiation Intracellular Protein Transport Receptor-mediated Endocytosis Autophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Low-density Lipoprotein Particle Receptor Catabolic Process Transferrin Transport Low-density Lipoprotein Particle Clearance Retrograde Transport, Endosome To Golgi Clathrin Coat Assembly Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Mitotic Spindle Organization Membrane Organization Clathrin-dependent Endocytosis Amyloid-beta Clearance By Transcytosis Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP	61 interacting genes: ACO1 AFTPH AMPH AP1B1 AP1G1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 DUX4 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL OPTN PICALM PPP1CA PPP1CC PRKACA PXN QARS1 SCYL2 SMAP1 SNX5 SNX9 SRC STAMBP SUMO2 SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		7414	1213
HPRD ID		01900	00350
Ensembl ID		ENSG00000035403	ENSG00000141367
Uniprot IDs		A0A024QZN4 B3KXA2 P18206 V9HWK2	A0A087WVQ6 Q00610
PDB IDs		1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW	2XZG 4G55 6E4L 6QNN 6QNP
Enriched GO Terms of Interacting Partners?
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