EFEMP2 and CCNK

Data Source:
HPRD (two hybrid)

		EFEMP2	CCNK
Description		EGF containing fibulin extracellular matrix protein 2	cyclin K
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GO Annotations	Cellular Component	Microfibril Extracellular Region Basement Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber Extracellular Vesicle	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding Protein Homodimerization Activity	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Aorta Development Elastic Fiber Assembly Aorta Smooth Muscle Tissue Morphogenesis Vascular Associated Smooth Muscle Cell Development Regulation Of Collagen Fibril Organization Positive Regulation Of Collagen Fibril Organization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell-matrix Adhesion	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Serine 2 Residues
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654) Birth weight ( 31043758) Body size at age 10 ( 32376654) Retinal detachment or retinal break ( 31816047)	Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		130 interacting genes: ADAMTSL4 AMMECR1 ANAPC11 AP1M1 APEX2 AQP1 ARRDC3 ATN1 ATXN1 ATXN7 BAG6 C3 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK CDPF1 CLPP CNNM3 COL8A1 CREB5 CXCL5 CYSRT1 DGCR6 DOK7 FAM107A FAM110A FAM124B FAM74A4 FAM90A1 FBXW5 FTO GFI1B GLRX3 HDAC4 HHEX HHIPL1 HOXA1 HPCAL1 HSD3B7 HSPA12B HSPBP1 IGFBP6 IL16 INCA1 ITGB5 KLF1 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-5 KRTAP26-1 KRTAP3-2 LBX1 LCE1A LCE1C LCE1E LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LINGO1 LNX1 MDFI MEOX2 MRPL12 MXI1 NEDD4L NOS3 NR1D2 NTM NUFIP2 OTX1 P2RX7 PIDD1 PITX1 PLSCR1 PLSCR4 PROP1 PRPF31 PRR32 PTGER3 RAB40B RBAK RBP3 RBPMS RERE RHOXF2 RHPN1 RIBC2 RNF138 SGTA SGTB SLC16A5 SLC23A1 SLC25A48 SPACA9 SPATA24 SPATA3 SPATA8 SPRY4 STK16 TCAF1 THAP7 TLE5 TLX3 TP53 TRIB3 TRIM42 UBQLN1 UBQLN4 USP21 ZNF263 ZNF345 ZNF426 ZNF558 ZNF57 ZNF581 ZNF587 ZNF638 ZNF670 ZNF699 ZNF768 ZNF774 ZNF837	52 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 CYSRT1 DDIT4L DVL3 EFEMP2 FAM168B FKBP6 HIVEP1 HMG20A HNRNPH1 HNRNPH2 HOMEZ HOXA1 HSFY1 HSFY2 KCNRG KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP4-12 KRTAP6-2 KRTAP8-1 LZTS2 MYCL NDC80 NECAB2 OXER1 PIN1 POLR1C POLR2A POU6F2 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RFX6 RHOXF2 RUNX1 STX11 TLE5 TSC22D4 USHBP1 USP54 ZNF446
Entrez ID		30008	8812
HPRD ID		05221	10352
Ensembl ID		ENSG00000172638	ENSG00000090061
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5	A0A024R6K1 O75909
PDB IDs		2KL7	2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX 6TD3
Enriched GO Terms of Interacting Partners?
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