TIMM10B and MBD3

Data Source:
BioGRID (two hybrid)

		TIMM10B	MBD3
Description		translocase of inner mitochondrial membrane 10B	methyl-CpG binding domain protein 3
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GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Intermembrane Space Protein Transporter Complex TIM22 Mitochondrial Import Inner Membrane Insertion Complex	Chromatin Heterochromatin Nucleoplasm Cytoplasm NuRD Complex Protein-containing Complex
	Molecular Function	Protein Binding Metal Ion Binding Protein Transporter Activity	DNA Binding Protein Binding Methyl-CpG Binding Nucleosomal DNA Binding
	Biological Process	Protein Targeting To Mitochondrion Cell-matrix Adhesion Protein Insertion Into Mitochondrial Inner Membrane	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development DNA Methylation-dependent Heterochromatin Assembly Brain Development Heart Development Aging Tissue Development Histone Acetylation Response To Nutrient Levels Response To Estradiol ATP-dependent Chromatin Remodeling Regulation Of DNA Methylation Embryonic Organ Development Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Mitochondrial protein import	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		5 interacting genes: EIF3F HGS KLHL38 MBD3 MEIS2	76 interacting genes: AGR2 ANKRD33 ASCL4 ATF7 AURKA BCL11B CCDC183 CCHCR1 CCNC CENPP CEP70 CEP76 CT55 ERCC6 EXOC4 FAM136A GADD45GIP1 GATAD2A GATAD2B GOLGA2 GOLGA6L9 H3-4 HDAC1 ICA1 IGFBP6 IK JUN KDM1A KDM5B KRT15 KRT16 LDOC1 LMO3 MAGEA2 MAGEA2B MBD2 MBD3L1 MBD3L2 MECOM MEIS3 MEOX1 MEOX2 MIPOL1 MKRN3 MTA2 MTUS2 MYOG NUTM1 PBX4 PDGFA PFDN6 PICK1 PKNOX2 PRKAR1B RAB3IP RBBP4 RBBP7 RCN3 REL RINT1 SDCBP SERTAD3 SMARCA4 SPEN STMN2 SYCE1 TBC1D19 TET1 TIMM10B TNNI1 TRIM54 TTC23 USP11 ZBTB7A ZNF277 ZNF655
Entrez ID		26515	53615
HPRD ID		16242	04653
Ensembl ID		ENSG00000132286	ENSG00000071655
Uniprot IDs		B2R4A9 Q9Y5J6	O95983
PDB IDs		7CGP	2MB7 6CC8 6CCG 6CEU 6CEV
Enriched GO Terms of Interacting Partners?
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