PEBP1 and MED10

Data Source:
HPRD (two hybrid)

		PEBP1	MED10
Description		phosphatidylethanolamine binding protein 1	mediator complex subunit 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Extracellular Exosome	Ubiquitin Ligase Complex Chromatin Nucleoplasm Mediator Complex
	Molecular Function	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Phosphatidylethanolamine Binding Enzyme Binding Protein Kinase Binding	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Negative Regulation Of Endopeptidase Activity Negative Regulation Of MAPK Cascade	Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II
Pathways		MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Copper
Diseases
GWAS		Blood protein levels ( 30072576) Morphine dose requirement in tonsillectomy and adenoidectomy surgery ( 24909733)
Interacting Genes		23 interacting genes: BRAF CACHD1 CHUK ERBB2 GRK2 GSDMB IKBKB MAP2K1 MAP3K14 MAP3K7 MAPK1 MED10 NKX3-1 NR2C2 PICK1 PPARD PRKCA PRKCB PRKCD PRKCG PRKCZ RAF1 STC2	12 interacting genes: ABI2 ARHGDIG ESR1 ESR2 FUCA1 HNF4A KDM4B MOB4 NAP1L1 PEBP1 SYCE1L TRIM45
Entrez ID		5037	84246
HPRD ID		06850	14680
Ensembl ID		ENSG00000089220	ENSG00000133398
Uniprot IDs		D9IAI1 P30086	Q9BTT4
PDB IDs		1BD9 1BEH 2L7W 2QYQ
Enriched GO Terms of Interacting Partners?
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