CDCA5 and IRAK3

Data Source:
BioGRID (two hybrid)

		CDCA5	IRAK3
Description		cell division cycle associated 5	interleukin 1 receptor associated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	Chromatin Binding Protein Binding Protein-containing Complex Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Mitotic Sister Chromatid Cohesion Mitotic Chromosome Condensation Mitotic Metaphase Plate Congression Positive Regulation Of Exit From Mitosis Cell Division Regulation Of Cohesin Loading	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Resolution of Sister Chromatid Cohesion	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS			Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		9 interacting genes: CDK1 IRAK3 KDM1A NAA10 NAA11 RPAIN SENP2 TTLL3 XRCC6	17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		113130	11213
HPRD ID		13016	05123
Ensembl ID		ENSG00000146670	ENSG00000090376
Uniprot IDs		A0A024R5D6 Q96FF9	Q9Y616
PDB IDs			5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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