ADH1B and PDE4DIP

Data Source:
BioGRID (two hybrid)

		ADH1B	PDE4DIP
Description		alcohol dehydrogenase 1B (class I), beta polypeptide	phosphodiesterase 4D interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Zinc Ion Binding	Protein Binding Enzyme Binding Molecular Adaptor Activity
	Biological Process	Retinoid Metabolic Process Ethanol Oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process	Cellular Protein-containing Complex Assembly Regulation Of Golgi Organization
Pathways		Ethanol oxidation
Drugs		NADH Fomepizole N-Benzylformamide 4-Iodopyrazole Nicotinamide adenine dinucleotide phosphate Cyclohexanol N-Heptylformamide Glycerin
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption ( 23743675 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 28485404 30643258 31959922 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 24166409 23456092 28714907 31591379 31090166 22004471) Alcohol dependence (desire to cut drinking) ( 31090166) Alcohol dependence (tolerance) ( 31090166) Alcohol dependence symptom count ( 31090166) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Initial pursuit acceleration ( 29064472) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lung cancer ( 28604730) Maximum habitual alcohol consumption ( 31151762) Metabolite levels ( 23823483) Oral cavity and pharyngeal cancer ( 21437268 27749845) Oral cavity cancer ( 27749845) Oropharynx cancer ( 27749845) Problematic alcohol use ( 32451486) Regular attendance at a pub or social club ( 29970889) Relative fat intake ( 32393786) Relative protein intake ( 32393786) Reticulocyte count ( 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Urinary sodium excretion ( 31409800)	Capecitabine sensitivity ( 22864933)
Interacting Genes		5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3	85 interacting genes: ADH1B AEN AKTIP ANKRD11 ARNT2 BYSL C1orf109 CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CLIP4 CWF19L2 EGR2 FAM161A FAM50B FAM74A4 FCHSD2 FES FHL1 GADD45G GFI1B GOLGA8EP GOLGA8F HAUS1 HOXB5 HOXC8 ITSN2 KDM1A KLC3 KLC4 KRAS KRT18 KRT31 LAMTOR3 LENG1 LIN37 LMO4 MAPRE3 MIF4GD MTUS2 MYBPC2 MYOM1 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 PYGM RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 TK1 TNIK TRAF4 TULP3 UTP14C VAC14 ZBTB24 ZBTB38 ZBTB4 ZFYVE21 ZKSCAN3 ZNF124 ZNF408 ZNF410 ZNF414 ZNF512B ZNF581 ZNF587 ZNF696 ZSCAN26
Entrez ID		125	9659
HPRD ID		00065	10482
Ensembl ID		ENSG00000196616	ENSG00000178104
Uniprot IDs		D6RHZ6 P00325 V9HW50	A0A075B749 A0A087WYE4 Q5VU43
PDB IDs		1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD
Enriched GO Terms of Interacting Partners?
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