NSA2 and IRAK3

Data Source:
BioGRID (two hybrid)

		NSA2	IRAK3
Description		NSA2 ribosome biogenesis factor	interleukin 1 receptor associated kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Preribosome, Large Subunit Precursor	Nucleus Cytoplasm Plasma Membrane
	Molecular Function	RNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Maturation Of 5.8S RRNA Maturation Of LSU-rRNA	Negative Regulation Of Cytokine-mediated Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Response To Virus Positive Regulation Of Macrophage Tolerance Induction Negative Regulation Of Macrophage Cytokine Production Cytokine-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Peptidoglycan Response To Lipopolysaccharide Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Protein-containing Complex Disassembly Response To Exogenous DsRNA Negative Regulation Of MAP Kinase Activity Negative Regulation Of Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways			MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS			Smooth-surface caries ( 24556642) White blood cell count (basophil) ( 29403010)
Interacting Genes		1 interacting genes: IRAK3	17 interacting genes: ADH1B ATP6V0B CD14 CDCA5 COPB1 ECM1 FOLR1 HOXB7 IRAK1 IRAK2 LDB1 MYD88 NONO NSA2 NTRK3 TICAM2 TRAF6
Entrez ID		10412	11213
HPRD ID		18191	05123
Ensembl ID		ENSG00000164346	ENSG00000090376
Uniprot IDs		A0A0A0MQZ6 O95478 Q5J7U2	Q9Y616
PDB IDs			5UKE 6RUU 6ZIW
Enriched GO Terms of Interacting Partners?
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