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DUX4 and MCM7
Data Source:
BioGRID
(pull down)
DUX4
MCM7
Description
double homeobox 4
minichromosome maintenance complex component 7
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Golgi Apparatus
Cytosol
Nuclear Membrane
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Membrane
MCM Complex
CMG Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Single-stranded 3'-5' DNA Helicase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of G0 To G1 Transition
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Cellular Response To DNA Damage Stimulus
Cell Population Proliferation
Regulation Of Phosphorylation
Response To Drug
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
124 interacting genes:
ACTG1
AP2A1
AP3D1
ARF1
ATP5F1C
C1QBP
CAND1
CAPN2
CAVIN1
CCT6A
CLTC
COPA
CSE1L
DDX21
DDX3X
DDX5
DES
DHX30
DHX36
DHX9
DYNC1H1
EEF2
EFTUD2
ENO1
EP300
EPRS1
FASN
FLNA
GAPDH
GARS1
HMGB1
HNRNPA1L2
HNRNPF
HNRNPH1
HNRNPK
HNRNPM
HNRNPU
HSPD1
IARS1
IGF2BP1
IGF2BP3
ILF3
IQGAP1
LDHA
MARS1
MCM7
MTHFD1
MYBBP1A
MYH10
MYH9
MYL6B
NCL
NPM1
PABPC1
PABPC4
PARP1
PFAS
PKM
PPP2R1A
PRKDC
PRPF8
RAN
RPL10
RPL10A
RPL12
RPL13
RPL15
RPL17
RPL18
RPL19
RPL21
RPL22
RPL23
RPL23A
RPL27A
RPL3
RPL30
RPL31
RPL35
RPL36
RPL4
RPL6
RPL7
RPL7A
RPL8
RPL9
RPN1
RPS10
RPS13
RPS14
RPS15
RPS15A
RPS16
RPS17
RPS18
RPS2
RPS20
RPS24
RPS25
RPS3
RPS3A
RPS4X
RPS6
RPS7
RPS8
RPS9
SF3B1
SHMT2
SLC25A3
SLC25A5
SLC25A6
SNRNP200
SRSF3
TCP1
TUBB
TUBB2A
TUBB3
TUBB6
VDAC1
VDAC2
VIM
XRCC5
XRCC6
YBX1
77 interacting genes:
ABI2
AK8
APP
ASB8
C8orf34
CCDC102B
CCND1
CCNH
CDC42
CDC45
CDC6
CDC7
CDK7
CDKN1B
CEP68
CHEK1
COG6
CRLS1
DBF4
DNAAF6
DUX4
ELOC
ESCO2
FHL2
GOLGA2
H3-4
HIF1A
IKBKG
IKZF3
INTS6
KIFC3
LINC01554
LNX2
MAGEA6
MBIP
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM8
MCMBP
MEOX2
MIPOL1
MNAT1
NAB2
NFKBIA
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
PLK1
PNMA1
RAD17
RB1
RBL1
RBL2
RBM8A
RBPMS
RINT1
RPA1
SMC1A
SNTA1
SP2
SSX2IP
TFIP11
TREX1
TRIM27
TRIM54
TRIM55
TRIM63
UBE3A
UBQLN1
USHBP1
Entrez ID
100288687
4176
HPRD ID
01154
Ensembl ID
ENSG00000260596
ENSG00000166508
Uniprot IDs
C3U3A0
Q9UBX2
A0A0S2Z4A5
C6EMX8
P33993
PDB IDs
5Z2S
5Z2T
5Z6Z
5ZFW
5ZFY
5ZFZ
6A8R
6DFY
6E8C
6U81
6U82
6XTX
6XTY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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