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DUX4 and DHX36
Data Source:
BioGRID
(pull down)
DUX4
DHX36
Description
double homeobox 4
DEAH-box helicase 36
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Golgi Apparatus
Cytosol
Nuclear Membrane
Chromosome, Telomeric Region
Intracellular Anatomical Structure
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Perikaryon
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
Magnesium Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
G-quadruplex RNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
RNA Binding
RNA Helicase Activity
Double-stranded RNA Binding
MRNA 3'-UTR Binding
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
MRNA 3'-UTR AU-rich Region Binding
Histone Deacetylase Binding
MRNA 5'-UTR Binding
G-quadruplex DNA Binding
Telomerase RNA Binding
Pre-miRNA Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of G0 To G1 Transition
Ossification
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Regulation Of Transcription By RNA Polymerase III
Spermatogenesis
RNA Secondary Structure Unwinding
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Positive Regulation Of MRNA 3'-end Processing
Positive Regulation Of Telomere Maintenance
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Positive Regulation Of Interferon-alpha Production
Cellular Response To Heat
Cellular Response To UV
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Regulation Of MRNA Stability
G-quadruplex DNA Unwinding
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Defense Response To Virus
Positive Regulation Of Cardioblast Differentiation
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Dendritic Spine Morphogenesis
3'-UTR-mediated MRNA Destabilization
Telomerase RNA Stabilization
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Positive Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Spermatogenesis
Cellular Response To Arsenite Ion
Positive Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Intracellular MRNA Localization
Positive Regulation Of Cytoplasmic Translation
Pathways
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Drugs
Diseases
GWAS
Blood protein levels (
29875488
)
Body mass index (
29273807
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Interacting Genes
124 interacting genes:
ACTG1
AP2A1
AP3D1
ARF1
ATP5F1C
C1QBP
CAND1
CAPN2
CAVIN1
CCT6A
CLTC
COPA
CSE1L
DDX21
DDX3X
DDX5
DES
DHX30
DHX36
DHX9
DYNC1H1
EEF2
EFTUD2
ENO1
EP300
EPRS1
FASN
FLNA
GAPDH
GARS1
HMGB1
HNRNPA1L2
HNRNPF
HNRNPH1
HNRNPK
HNRNPM
HNRNPU
HSPD1
IARS1
IGF2BP1
IGF2BP3
ILF3
IQGAP1
LDHA
MARS1
MCM7
MTHFD1
MYBBP1A
MYH10
MYH9
MYL6B
NCL
NPM1
PABPC1
PABPC4
PARP1
PFAS
PKM
PPP2R1A
PRKDC
PRPF8
RAN
RPL10
RPL10A
RPL12
RPL13
RPL15
RPL17
RPL18
RPL19
RPL21
RPL22
RPL23
RPL23A
RPL27A
RPL3
RPL30
RPL31
RPL35
RPL36
RPL4
RPL6
RPL7
RPL7A
RPL8
RPL9
RPN1
RPS10
RPS13
RPS14
RPS15
RPS15A
RPS16
RPS17
RPS18
RPS2
RPS20
RPS24
RPS25
RPS3
RPS3A
RPS4X
RPS6
RPS7
RPS8
RPS9
SF3B1
SHMT2
SLC25A3
SLC25A5
SLC25A6
SNRNP200
SRSF3
TCP1
TUBB
TUBB2A
TUBB3
TUBB6
VDAC1
VDAC2
VIM
XRCC5
XRCC6
YBX1
71 interacting genes:
DUX4
IL7R
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F2
MIRLET7G
MIRLET7I
TLR1
ZFP36
Entrez ID
100288687
170506
HPRD ID
09918
Ensembl ID
ENSG00000260596
ENSG00000174953
Uniprot IDs
C3U3A0
Q9UBX2
Q9H2U1
PDB IDs
5Z2S
5Z2T
5Z6Z
5ZFW
5ZFY
5ZFZ
6A8R
6DFY
6E8C
6U81
6U82
2N16
2N21
6Q6R
Enriched GO Terms of Interacting Partners
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