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DUX4 and AP2A1
Data Source:
BioGRID
(pull down)
DUX4
AP2A1
Description
double homeobox 4
adaptor related protein complex 2 subunit alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Golgi Apparatus
Cytosol
Nuclear Membrane
Cytosol
Plasma Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
AP-2 Adaptor Complex
Clathrin Coat Of Trans-Golgi Network Vesicle
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Filopodium Tip
Endolysosome Membrane
Clathrin-coated Endocytic Vesicle
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Protein C-terminus Binding
Protein Kinase Binding
Clathrin Adaptor Activity
Protein-containing Complex Binding
Low-density Lipoprotein Particle Receptor Binding
Cargo Adaptor Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of G0 To G1 Transition
Intracellular Protein Transport
Golgi To Endosome Transport
Endocytosis
Receptor-mediated Endocytosis
Positive Regulation Of Neuron Projection Development
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Low-density Lipoprotein Particle Receptor Catabolic Process
Low-density Lipoprotein Particle Clearance
Ephrin Receptor Signaling Pathway
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Defense Response To Virus By Virus
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Clathrin-dependent Endocytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways
Nef Mediated CD4 Down-regulation
Retrograde neurotrophin signalling
Retrograde neurotrophin signalling
Nef Mediated CD8 Down-regulation
MHC class II antigen presentation
EPH-ephrin mediated repulsion of cells
Trafficking of GluR2-containing AMPA receptors
Recycling pathway of L1
Recycling pathway of L1
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
VLDLR internalisation and degradation
LDL clearance
Potential therapeutics for SARS
Drugs
Diseases
GWAS
Interacting Genes
124 interacting genes:
ACTG1
AP2A1
AP3D1
ARF1
ATP5F1C
C1QBP
CAND1
CAPN2
CAVIN1
CCT6A
CLTC
COPA
CSE1L
DDX21
DDX3X
DDX5
DES
DHX30
DHX36
DHX9
DYNC1H1
EEF2
EFTUD2
ENO1
EP300
EPRS1
FASN
FLNA
GAPDH
GARS1
HMGB1
HNRNPA1L2
HNRNPF
HNRNPH1
HNRNPK
HNRNPM
HNRNPU
HSPD1
IARS1
IGF2BP1
IGF2BP3
ILF3
IQGAP1
LDHA
MARS1
MCM7
MTHFD1
MYBBP1A
MYH10
MYH9
MYL6B
NCL
NPM1
PABPC1
PABPC4
PARP1
PFAS
PKM
PPP2R1A
PRKDC
PRPF8
RAN
RPL10
RPL10A
RPL12
RPL13
RPL15
RPL17
RPL18
RPL19
RPL21
RPL22
RPL23
RPL23A
RPL27A
RPL3
RPL30
RPL31
RPL35
RPL36
RPL4
RPL6
RPL7
RPL7A
RPL8
RPL9
RPN1
RPS10
RPS13
RPS14
RPS15
RPS15A
RPS16
RPS17
RPS18
RPS2
RPS20
RPS24
RPS25
RPS3
RPS3A
RPS4X
RPS6
RPS7
RPS8
RPS9
SF3B1
SHMT2
SLC25A3
SLC25A5
SLC25A6
SNRNP200
SRSF3
TCP1
TUBB
TUBB2A
TUBB3
TUBB6
VDAC1
VDAC2
VIM
XRCC5
XRCC6
YBX1
28 interacting genes:
AAGAB
AP2S1
BIN1
CLINT1
DEK
DNM2
DPYSL2
DUX4
EHD1
EPN1
EPS15
GHR
HIP1
NAGPA
NUMB
PICALM
PIN1
RAB11FIP2
RIT1
SHBG
SHC1
SMAD9
SNAP29
SYNJ1
SYT3
SYT7
TOE1
UBC
Entrez ID
100288687
160
HPRD ID
03016
Ensembl ID
ENSG00000260596
ENSG00000196961
Uniprot IDs
C3U3A0
Q9UBX2
O95782
PDB IDs
5Z2S
5Z2T
5Z6Z
5ZFW
5ZFY
5ZFZ
6A8R
6DFY
6E8C
6U81
6U82
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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