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DUX4 and FASN
Data Source:
BioGRID
(pull down)
DUX4
FASN
Description
double homeobox 4
fatty acid synthase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Golgi Apparatus
Cytosol
Nuclear Membrane
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Melanosome
Glycogen Granule
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
[acyl-carrier-protein] S-acetyltransferase Activity
[acyl-carrier-protein] S-malonyltransferase Activity
3-oxoacyl-[acyl-carrier-protein] Synthase Activity
3-oxoacyl-[acyl-carrier-protein] Reductase (NADPH) Activity
3-hydroxypalmitoyl-[acyl-carrier-protein] Dehydratase Activity
Oleoyl-[acyl-carrier-protein] Hydrolase Activity
Protein Binding
(3R)-hydroxymyristoyl-[acyl-carrier-protein] Dehydratase Activity
3-hydroxydecanoyl-[acyl-carrier-protein] Dehydratase Activity
Myristoyl-[acyl-carrier-protein] Hydrolase Activity
Palmitoyl-[acyl-carrier-protein] Hydrolase Activity
Phosphopantetheine Binding
Identical Protein Binding
Cadherin Binding
Enoyl-[acyl-carrier-protein] Reductase (NADPH, A-specific) Activity
3-hydroxyoctanoyl-[acyl-carrier-protein] Dehydratase Activity
3-oxo-glutaryl-[acp] Methyl Ester Reductase Activity
3-oxo-pimeloyl-[acp] Methyl Ester Reductase Activity
Biological Process
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Multicellular Organism Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of G0 To G1 Transition
Osteoblast Differentiation
Glandular Epithelial Cell Development
Acetyl-CoA Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Ether Lipid Biosynthetic Process
Neutrophil Differentiation
Monocyte Differentiation
Mammary Gland Development
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cholesterol Biosynthetic Process
Fatty-acyl-CoA Biosynthetic Process
Cellular Response To Interleukin-4
Establishment Of Endothelial Intestinal Barrier
Pathways
ChREBP activates metabolic gene expression
Vitamin B5 (pantothenate) metabolism
Activation of gene expression by SREBF (SREBP)
Fatty acyl-CoA biosynthesis
Fatty acyl-CoA biosynthesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs
Cerulenin
Orlistat
Diseases
GWAS
Blood protein levels (
30072576
)
Major depressive disorder (
27777418
)
Malate levels (
31560688
)
Refractive error (
32231278
)
Interacting Genes
124 interacting genes:
ACTG1
AP2A1
AP3D1
ARF1
ATP5F1C
C1QBP
CAND1
CAPN2
CAVIN1
CCT6A
CLTC
COPA
CSE1L
DDX21
DDX3X
DDX5
DES
DHX30
DHX36
DHX9
DYNC1H1
EEF2
EFTUD2
ENO1
EP300
EPRS1
FASN
FLNA
GAPDH
GARS1
HMGB1
HNRNPA1L2
HNRNPF
HNRNPH1
HNRNPK
HNRNPM
HNRNPU
HSPD1
IARS1
IGF2BP1
IGF2BP3
ILF3
IQGAP1
LDHA
MARS1
MCM7
MTHFD1
MYBBP1A
MYH10
MYH9
MYL6B
NCL
NPM1
PABPC1
PABPC4
PARP1
PFAS
PKM
PPP2R1A
PRKDC
PRPF8
RAN
RPL10
RPL10A
RPL12
RPL13
RPL15
RPL17
RPL18
RPL19
RPL21
RPL22
RPL23
RPL23A
RPL27A
RPL3
RPL30
RPL31
RPL35
RPL36
RPL4
RPL6
RPL7
RPL7A
RPL8
RPL9
RPN1
RPS10
RPS13
RPS14
RPS15
RPS15A
RPS16
RPS17
RPS18
RPS2
RPS20
RPS24
RPS25
RPS3
RPS3A
RPS4X
RPS6
RPS7
RPS8
RPS9
SF3B1
SHMT2
SLC25A3
SLC25A5
SLC25A6
SNRNP200
SRSF3
TCP1
TUBB
TUBB2A
TUBB3
TUBB6
VDAC1
VDAC2
VIM
XRCC5
XRCC6
YBX1
11 interacting genes:
ADIPOQ
AKT1
DUX4
EWSR1
LNX1
MTDH
NDRG1
PRR12
PTEN
SUMO2
YWHAQ
Entrez ID
100288687
2194
HPRD ID
02567
Ensembl ID
ENSG00000260596
ENSG00000169710
Uniprot IDs
C3U3A0
Q9UBX2
P49327
PDB IDs
5Z2S
5Z2T
5Z6Z
5ZFW
5ZFY
5ZFZ
6A8R
6DFY
6E8C
6U81
6U82
1XKT
2CG5
2JFD
2JFK
2PX6
3HHD
3TJM
4PIV
4W82
4W9N
4Z49
5C37
6NNA
Enriched GO Terms of Interacting Partners
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