MCM7 and AK8

Data Source:
BioGRID (two hybrid)

		MCM7	AK8
Description		minichromosome maintenance complex component 7	adenylate kinase 8
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex CMG Complex	Cytoplasm Cytosol Axoneme Sperm Flagellum
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded 3'-5' DNA Helicase Activity	Adenylate Kinase Activity Cytidylate Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Population Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Nucleoside Diphosphate Phosphorylation Nucleoside Triphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Ventricular System Development Nucleoside Monophosphate Phosphorylation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Interconversion of nucleotide di- and triphosphates
Drugs			Bis(Adenosine)-5'-Pentaphosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Obesity-related traits ( 23251661)
Interacting Genes		77 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 DUX4 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM55 TRIM63 UBE3A UBQLN1 USHBP1	16 interacting genes: ALKBH3 CCDC102B CDK18 CNTF DPY30 FBXO7 HAUS1 MAP3K7CL MCM7 MID1IP1 PRMT6 RBM39 SMG9 SYT17 UBE2Z ZMAT2
Entrez ID		4176	158067
HPRD ID		01154	12991
Ensembl ID		ENSG00000166508	ENSG00000165695
Uniprot IDs		A0A0S2Z4A5 C6EMX8 P33993	Q96MA6
PDB IDs		6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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