MCM7 and C8orf34

Data Source:
BioGRID (two hybrid)

		MCM7	C8orf34
Description		minichromosome maintenance complex component 7	chromosome 8 open reading frame 34
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex CMG Complex
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Population Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Coronary artery disease ( 33020668) Dupuytren's disease ( 21732829) Hip circumference adjusted for BMI ( 28552196) Manganese levels ( 26025379) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Obesity-related traits ( 23251661) Response to irinotecan in non-small-cell lung cancer ( 22664479)
Interacting Genes		77 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 DUX4 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM55 TRIM63 UBE3A UBQLN1 USHBP1	9 interacting genes: AKAP7 MCM7 MCRS1 MTUS2 TCEANC UBC UTP14C ZNF319 ZNF655
Entrez ID		4176	116328
HPRD ID		01154	18281
Ensembl ID		ENSG00000166508	ENSG00000165084
Uniprot IDs		A0A0S2Z4A5 C6EMX8 P33993	Q49A92
PDB IDs		6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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