TRIM69 and KRT17

Data Source:
BioGRID (two hybrid)

		TRIM69	KRT17
Description		tripartite motif containing 69	keratin 17
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck	Cytosol Intermediate Filament Intermediate Filament Cytoskeleton Cell Periphery
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Structural Molecule Activity Protein Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination	Positive Regulation Of Cell Growth Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development Cornification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Keratinization Formation of the cornified envelope
Drugs
Diseases			Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	11 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 SNAPIN TRIM69 ZDHHC17
Entrez ID		140691	3872
HPRD ID		11518	01019
Ensembl ID		ENSG00000185880	ENSG00000128422
Uniprot IDs		H0YL66 Q86WT6	Q04695 Q14666
PDB IDs		4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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