TRIM69 and BEX2

Data Source:
BioGRID (two hybrid)

		TRIM69	BEX2
Description		tripartite motif containing 69	brain expressed X-linked 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck	Nucleus Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Protein Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination	Apoptotic Process Cell Cycle Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)
Interacting Genes		53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	92 interacting genes: AKAP9 AURKA BCAR3 BHLHB9 BLZF1 BORCS6 BRMS1 CALCOCO2 CCDC197 CCDC57 CCDC85B CCDC88B CDR2 CEP70 COG4 CTAG1A CTAG1B CYSRT1 EXOC8 FGFR2 FSD2 FST HSF2BP HSPB2 HSPB2-C11orf52 KLHL20 KNSTRN KRT15 KRT19 KRT27 KRT31 KRT34 KRT38 KRT39 KRT40 KRT6A KRT75 KRTAP10-8 KRTAP11-1 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP21-2 KRTAP3-3 KRTAP4-12 KRTAP5-9 KRTAP6-2 KRTAP6-3 LCN2 LDOC1 LMO2 LZTS2 MAGEA11 MAGEA2 MAGEA2B MAGEA4 MDFI MIPOL1 MKRN3 MORN3 MRPL38 MSS51 MTUS2 NECAB2 NFKBID OIP5 OMP PIK3CA PLA2G10 PLEKHG4 PNMA1 PPM1D PRDM14 PTPN11 ROPN1L SERTAD3 SPRED1 SPRY3 SSX2IP SYCE1 TACC3 TRAF1 TRAF2 TRIM27 TRIM42 TRIM69 TRIM73 TRIP6 USHBP1 VPS28 ZDHHC17 ZNF19
Entrez ID		140691	84707
HPRD ID		11518	06484
Ensembl ID		ENSG00000185880	ENSG00000133134
Uniprot IDs		H0YL66 Q86WT6	Q9BXY8
PDB IDs		4NQJ 6YXE
Enriched GO Terms of Interacting Partners?
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