TRIM69 and TNNT2

Data Source:
BioGRID (two hybrid)

		TRIM69	TNNT2
Description		tripartite motif containing 69	troponin T2, cardiac type
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding
	Biological Process	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination	Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)
Interacting Genes		53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69
Entrez ID		140691	7139
HPRD ID		11518	01844
Ensembl ID		ENSG00000185880	ENSG00000118194
Uniprot IDs		H0YL66 Q86WT6	A0A0A0MRJ5 P45379 Q15607
PDB IDs		4NQJ 6YXE	1J1D 1J1E 4Y99 6KN7 6KN8
Enriched GO Terms of Interacting Partners?
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