TRIM69 and IYD

Data Source:
BioGRID (two hybrid)

		TRIM69	IYD
Description		tripartite motif containing 69	iodotyrosine deiodinase
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Nuclear Speck	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Iodide Peroxidase Activity Protein Binding FMN Binding Oxidoreductase Activity
	Biological Process	Protein Polyubiquitination Apoptotic Process Protein Ubiquitination	Tyrosine Metabolic Process Thyroid Hormone Generation Thyroid Hormone Metabolic Process Cellular Oxidant Detoxification
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Thyroxine biosynthesis
Drugs			3,5-Diiodotyrosine
Diseases			Thyroid dyshormonogenesis; Dyshormogenetic goiter
GWAS		Estimated glomerular filtration rate in non-diabetics ( 31451708)	Anger ( 24489884)
Interacting Genes		53 interacting genes: AIFM2 APP ASNS ATP5MC1 BEX2 BIN3 C4orf45 CDSN DVL1 ETFDH FAM110A FAM161A FAM90A1 FKBP1B GEM HAUS1 HGS IYD KLHL38 KRT17 LARP1B LYSMD1 MAGEA4 MAJIN MED20 MID2 NEK8 NTAQ1 PML POLR3K PPP1R18 RECK RINT1 RSPH14 SF1 SF3A3 SKIL STMN3 SYCE2 SYNE4 TNNT2 TRIM44 TRIM54 TRIM55 TRIM63 UBE2D1 UBE2D3 UBE2E1 UBE2H UBE2N WASHC1 WWOX ZNF483	1 interacting genes: TRIM69
Entrez ID		140691	389434
HPRD ID		11518	16668
Ensembl ID		ENSG00000185880	ENSG00000009765
Uniprot IDs		H0YL66 Q86WT6	Q2VPV9 Q6PHW0
PDB IDs		4NQJ 6YXE	4TTB 4TTC 5YAK
Enriched GO Terms of Interacting Partners?
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