PDLIM7 and GEM

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		PDLIM7	GEM
Description		PDZ and LIM domain 7	GTP binding protein overexpressed in skeletal muscle
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GO Annotations	Cellular Component	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Cell Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		RET signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778) Pulse pressure ( 30578418)
Interacting Genes		34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	41 interacting genes: A2M AHCYL1 APOH BLZF1 BMP1 CALM1 CCDC102B CLDN15 CLEC4G COG8 CTSL DEUP1 GMIP GOLGA2 IKZF3 INO80E KCTD9 KLC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 LZTS2 NDUFAF3 NDUFS8 NOTCH2NLA PDLIM7 PNMA1 RNF7 RUNDC3A SDHB SSX2IP TCF4 TFIP11 TRAF1 TRIM23 TRIM27 TRIM54 VTN YBEY YWHAB
Entrez ID		9260	2669
HPRD ID		10436	11553
Ensembl ID		ENSG00000196923	ENSG00000164949
Uniprot IDs		Q9NR12	A0A024R9F5 P55040
PDB IDs		2Q3G	2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?
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