GEM and VTN

Number of citations of the paper that reports this interaction (PubMedID 18624398)
14

Data Source:
BioGRID (two hybrid)

		GEM	VTN
Description		GTP binding protein overexpressed in skeletal muscle	vitronectin
Image
GO Annotations	Cellular Component	Cell Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Intracellular Membrane-bounded Organelle Rough Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle
	Molecular Function	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Polymerization Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration
Pathways			Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade
Drugs			Abciximab Zinc Copper
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778) Pulse pressure ( 30578418)	Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Osteoprotegerin levels ( 25080503)
Interacting Genes		41 interacting genes: A2M AHCYL1 APOH BLZF1 BMP1 CALM1 CCDC102B CLDN15 CLEC4G COG8 CTSL DEUP1 GMIP GOLGA2 IKZF3 INO80E KCTD9 KLC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 LZTS2 NDUFAF3 NDUFS8 NOTCH2NLA PDLIM7 PNMA1 RNF7 RUNDC3A SDHB SSX2IP TCF4 TFIP11 TRAF1 TRIM23 TRIM27 TRIM54 VTN YBEY YWHAB	43 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA
Entrez ID		2669	7448
HPRD ID		11553	01902
Ensembl ID		ENSG00000164949	ENSG00000109072
Uniprot IDs		A0A024R9F5 P55040	D9ZGG2 P04004
PDB IDs		2CJW 2G3Y 2HT6	1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E
Enriched GO Terms of Interacting Partners?
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