PDLIM7 and PAK5

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
HPRD (two hybrid)

		PDLIM7	PAK5
Description		PDZ and LIM domain 7	p21 (RAC1) activated kinase 5
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GO Annotations	Cellular Component	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Nucleoplasm Cytoplasm Mitochondrion Synapse
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Signal Transduction Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Cell Proliferation Cell Migration Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		RET signaling	Activation of RAC1
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Atopy ( 28927820) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701)
Interacting Genes		34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	21 interacting genes: ARMC7 ATPAF2 BAD CARD9 CCNG1 CDC42 CRBN EMD EXOSC1 FHL3 GCC1 INKA1 LENG1 LZTS2 PDLIM7 PRPF31 PSMF1 RAC1 SORBS3 TUBGCP4 UXT
Entrez ID		9260	57144
HPRD ID		10436	06423
Ensembl ID		ENSG00000196923	ENSG00000101349
Uniprot IDs		Q9NR12	B0AZM9 Q9P286
PDB IDs		2Q3G	2F57
Enriched GO Terms of Interacting Partners?
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