GEM and KLC3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GEM	KLC3
Description		GTP binding protein overexpressed in skeletal muscle	kinesin light chain 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Cytoplasm Kinesin Complex Microtubule Motile Cilium Ciliary Rootlet Neuron Projection
	Molecular Function	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	Microtubule Motor Activity Protein Binding Microtubule Binding Kinesin Binding
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity	Axo-dendritic Transport
Pathways			MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778) Pulse pressure ( 30578418)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971)
Interacting Genes		41 interacting genes: A2M AHCYL1 APOH BLZF1 BMP1 CALM1 CCDC102B CLDN15 CLEC4G COG8 CTSL DEUP1 GMIP GOLGA2 IKZF3 INO80E KCTD9 KLC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 LZTS2 NDUFAF3 NDUFS8 NOTCH2NLA PDLIM7 PNMA1 RNF7 RUNDC3A SDHB SSX2IP TCF4 TFIP11 TRAF1 TRIM23 TRIM27 TRIM54 VTN YBEY YWHAB	37 interacting genes: ABI3 BBS5 BICDL2 CBY2 CCNH CENPP CEP57L1 CROCC DTX2 GEM IHO1 IMP3 KDM1A KIF5A KIF5B KIF5C KRT13 KRT15 MBIP NDC80 NECAB2 NEFL PDE4DIP QARS1 SMARCB1 SNAP47 STX11 TCF4 TSNAX USHBP1 VPS52 WAC YWHAG YWHAH YWHAQ ZNF417 ZNF572
Entrez ID		2669	147700
HPRD ID		11553	03212
Ensembl ID		ENSG00000164949	ENSG00000104892
Uniprot IDs		A0A024R9F5 P55040	A0A024R0V3 Q6P597
PDB IDs		2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?
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