GEM and NDUFS8

Number of citations of the paper that reports this interaction (PubMedID 18624398)
14

Data Source:
BioGRID (two hybrid)

		GEM	NDUFS8
Description		GTP binding protein overexpressed in skeletal muscle	NADH:ubiquinone oxidoreductase core subunit S8
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GO Annotations	Cellular Component	Cell Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle	Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly
Pathways			Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778) Pulse pressure ( 30578418)
Interacting Genes		41 interacting genes: A2M AHCYL1 APOH BLZF1 BMP1 CALM1 CCDC102B CLDN15 CLEC4G COG8 CTSL DEUP1 GMIP GOLGA2 IKZF3 INO80E KCTD9 KLC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 LZTS2 NDUFAF3 NDUFS8 NOTCH2NLA PDLIM7 PNMA1 RNF7 RUNDC3A SDHB SSX2IP TCF4 TFIP11 TRAF1 TRIM23 TRIM27 TRIM54 VTN YBEY YWHAB	2 interacting genes: GEM UBC
Entrez ID		2669	4728
HPRD ID		11553	03683
Ensembl ID		ENSG00000164949	ENSG00000110717
Uniprot IDs		A0A024R9F5 P55040	O00217
PDB IDs		2CJW 2G3Y 2HT6	5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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