PDLIM7 and TPM2

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PDLIM7	TPM2
Description		PDZ and LIM domain 7	tropomyosin 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development	Muscle Contraction Actin Filament Organization Muscle Filament Sliding Regulation Of ATPase Activity
Pathways		RET signaling	Striated Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases			Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	12 interacting genes: ACTA1 ACTB GRK2 JUN NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL TPM1
Entrez ID		9260	7169
HPRD ID		10436	11768
Ensembl ID		ENSG00000196923	ENSG00000198467
Uniprot IDs		Q9NR12	A7XZE4 P07951 Q5TCU3 V9HW25
PDB IDs		2Q3G
Enriched GO Terms of Interacting Partners?
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