PDLIM7 and SH2B2

Number of citations of the paper that reports this interaction (PubMedID 15946664)
11

Data Source:
HPRD (in vivo, two hybrid)

		PDLIM7	SH2B2
Description		PDZ and LIM domain 7	SH2B adaptor protein 2
Image
GO Annotations	Cellular Component	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway
Pathways		RET signaling	Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Type 2 diabetes ( 31049640)
Interacting Genes		34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165	22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK
Entrez ID		9260	10603
HPRD ID		10436	16097
Ensembl ID		ENSG00000196923	ENSG00000160999
Uniprot IDs		Q9NR12	O14492
PDB IDs		2Q3G	1Q2H
Enriched GO Terms of Interacting Partners?
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