UBE2S and RBCK1

Number of citations of the paper that reports this interaction (PubMedID 19549727)
67

Data Source:
BioGRID (two hybrid)

		UBE2S	RBCK1
Description		ubiquitin conjugating enzyme E2 S	RANBP2-type and C3HC4-type zinc finger containing 1
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GO Annotations	Cellular Component	Cell Nucleoplasm Anaphase-promoting Complex Cytosol	Ubiquitin Ligase Complex Cytosol LUBAC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Night sleep phenotypes ( 27126917)
Interacting Genes		40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1	54 interacting genes: APP ARNT2 BACH1 CREBBP HGS HOXA1 IREB2 MALT1 MAP3K1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7
Entrez ID		27338	10616
HPRD ID		15603	16643
Ensembl ID		ENSG00000108106	ENSG00000125826
Uniprot IDs		Q16763	A6PVJ6 A6PVK0 Q9BYM8
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK	2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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