RBCK1 and SOCS6

Number of citations of the paper that reports this interaction (PubMedID 16643902)
10

Data Source:
HPRD (in vivo, two hybrid)

		RBCK1	SOCS6
Description		RANBP2-type and C3HC4-type zinc finger containing 1	suppressor of cytokine signaling 6
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Defense Response JAK-STAT Cascade Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation Negative Regulation Of T Cell Activation
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Regulation of KIT signaling Neddylation
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		54 interacting genes: APP ARNT2 BACH1 CREBBP HGS HOXA1 IREB2 MALT1 MAP3K1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	31 interacting genes: ACVR1 APPL1 BMPR1B CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC FRS3 INSR IRS2 IRS4 KDM1A KIT LNX1 PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		10616	9306
HPRD ID		16643	05491
Ensembl ID		ENSG00000125826	ENSG00000170677
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	A0A024R379 O14544
PDB IDs		2CRC 2LGY 4DBG	2VIF
Enriched GO Terms of Interacting Partners?
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