UBE2S and ANAPC1

Number of citations of the paper that reports this interaction (PubMedID 25306923)
47

Data Source:
BioGRID (pull down)

		UBE2S	ANAPC1
Description		ubiquitin conjugating enzyme E2 S	anaphase promoting complex subunit 1
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 23817571) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Corneal endothelial cell density ( 30894546) Corneal hysteresis ( 31246245 30894546) Corneal resistance factor ( 31246245 30894546) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010 30054594) Obesity-related traits ( 23251661)
Interacting Genes		40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1	8 interacting genes: CDC20 FBXO5 FZR1 HRAS MDC1 UBC UBE2S WBP2
Entrez ID		27338	64682
HPRD ID		15603	09769
Ensembl ID		ENSG00000108106	ENSG00000153107
Uniprot IDs		Q16763	Q9H1A4
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK	4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 5LGG 6Q6G
Enriched GO Terms of Interacting Partners?
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