RBCK1 and SYCE1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RBCK1	SYCE1
Description		RANBP2-type and C3HC4-type zinc finger containing 1	synaptonemal complex central element protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	Synaptonemal Complex Central Element Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Synaptonemal Complex Assembly Cell Division
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Meiotic synapsis
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)
Interacting Genes		54 interacting genes: APP ARNT2 BACH1 CREBBP HGS HOXA1 IREB2 MALT1 MAP3K1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	36 interacting genes: ALOX5 ARNT2 BFSP2 CBY2 CCDC102B CINP CNN1 CYTH3 EDRF1 FAM161A HAUS1 HMG20B HOOK1 HSPB1 HSPB7 IQUB KIFC3 KRT18 LMNA MPV17 MRFAP1L1 NME7 PSTPIP1 RBCK1 SCNM1 SKA1 SMARCE1 SSX2 STX19 TFIP11 TPM1 TPM3 TRAF1 TSG101 WASHC3 ZNF124
Entrez ID		10616	93426
HPRD ID		16643	12598
Ensembl ID		ENSG00000125826	ENSG00000171772
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	A0A0B4J1R9 Q8N0S2
PDB IDs		2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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