RBCK1 and TRIM65

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		RBCK1	TRIM65
Description		RANBP2-type and C3HC4-type zinc finger containing 1	tripartite motif containing 65
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	Zinc Ion Binding
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Autophagy
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Body mass index ( 29273807) Psoriasis ( 28537254) White matter hyperintensity burden ( 21681796 25663218) White matter hyperintensity volume ( 30659137)
Interacting Genes		54 interacting genes: APP ARNT2 BACH1 CREBBP HGS HOXA1 IREB2 MALT1 MAP3K1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	11 interacting genes: ANAPC11 IFIH1 MARCHF7 MKRN3 RBCK1 SRPK1 TNRC6A UBE2D2 UBE2U UBE2Z UBE3A
Entrez ID		10616	201292
HPRD ID		16643	15569
Ensembl ID		ENSG00000125826	ENSG00000141569
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	Q6PJ69
PDB IDs		2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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