RBCK1 and OTUB2

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		RBCK1	OTUB2
Description		RANBP2-type and C3HC4-type zinc finger containing 1	OTU deubiquitinase, ubiquitin aldehyde binding 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)
Interacting Genes		54 interacting genes: APP ARNT2 BACH1 CREBBP HGS HOXA1 IREB2 MALT1 MAP3K1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	35 interacting genes: APP ARRDC3 CPSF6 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28
Entrez ID		10616	78990
HPRD ID		16643	07620
Ensembl ID		ENSG00000125826	ENSG00000089723
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	Q96DC9
PDB IDs		2CRC 2LGY 4DBG	1TFF 4FJV
Enriched GO Terms of Interacting Partners?
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