UBE2S and FBXO5

Number of citations of the paper that reports this interaction (PubMedID 29875408)
7

Data Source:
BioGRID (enzymatic study)

		UBE2S	FBXO5
Description		ubiquitin conjugating enzyme E2 S	F-box protein 5
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Meiotic Spindle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Oocyte Maturation Regulation Of DNA Replication Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of DNA Endoreduplication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence Negative Regulation Of Response To DNA Damage Stimulus
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription
Drugs
Diseases
GWAS			Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)
Interacting Genes		40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1	16 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDK1 EVI5 FZR1 SKP1 SRC TPM3 UBE2C UBE2S
Entrez ID		27338	26271
HPRD ID		15603	09348
Ensembl ID		ENSG00000108106	ENSG00000112029
Uniprot IDs		Q16763	Q9UKT4
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK	2M6N 4UI9
Enriched GO Terms of Interacting Partners?
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