UBE2S and OTUB1

Number of citations of the paper that reports this interaction (PubMedID 20622874)
119

Data Source:
BioGRID (enzymatic study)

		UBE2S	OTUB1
Description		ubiquitin conjugating enzyme E2 S	OTU deubiquitinase, ubiquitin aldehyde binding 1
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GO Annotations	Cellular Component	Cell Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Interleukin-1 Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756)
Interacting Genes		40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1	51 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D4 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28
Entrez ID		27338	55611
HPRD ID		15603	08493
Ensembl ID		ENSG00000108106	ENSG00000167770
Uniprot IDs		Q16763	B3KUV5 Q96FW1
PDB IDs		1ZDN 5BNB 5L9T 6QH3 6QHK	2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?
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