RBCK1 and NDUFAF3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RBCK1	NDUFAF3
Description		RANBP2-type and C3HC4-type zinc finger containing 1	NADH:ubiquinone oxidoreductase complex assembly factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol LUBAC Complex	Nucleus Mitochondrial Inner Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding	Protein Binding
	Biological Process	Protein Polyubiquitination I-kappaB Kinase/NF-kappaB Signaling Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Necroptotic Process Protein Linear Polyubiquitination Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Antigen processing: Ubiquitination & Proteasome degradation	Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Night sleep phenotypes ( 27126917)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Ulcerative colitis ( 28067908)
Interacting Genes		54 interacting genes: APP ARNT2 BACH1 CREBBP HGS HOXA1 IREB2 MALT1 MAP3K1 MKRN2 NAA10 NDUFAF3 NEDD4 NR1I2 OTUB2 OTUD6A PAN2 PCGF2 PRKCA PRKN PSMD4 RNF181 RNF31 SMURF1 SOCS6 SYCE1 TNFAIP3 TP53 TRAF1 TRIM21 TRIM25 TRIM65 TRIML1 TSSK3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2K UBE2L3 UBE2L6 UBE2N UBE2S UBE2U UCHL5 UHRF2 USP15 USP2 USP21 USP32 USP49 USP7	8 interacting genes: GEM KRTAP10-3 LSM1 NDUFAF4 RBCK1 REL SCAP SNRPA
Entrez ID		10616	25915
HPRD ID		16643	16809
Ensembl ID		ENSG00000125826	ENSG00000178057
Uniprot IDs		A6PVJ6 A6PVK0 Q9BYM8	A4FU71 Q9BU61 Q9Y3Z0
PDB IDs		2CRC 2LGY 4DBG
Enriched GO Terms of Interacting Partners?
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