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GIT2 and GRK2
Data Source:
HPRD
(two hybrid, in vivo)
GIT2
GRK2
Description
GIT ArfGAP 2
G protein-coupled receptor kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Focal Adhesion
Cytoplasm
Cytosol
Plasma Membrane
Cilium
Membrane
Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
Metal Ion Binding
Protein Kinase Activity
G Protein-coupled Receptor Kinase Activity
Protein Binding
ATP Binding
Alpha-2A Adrenergic Receptor Binding
Edg-2 Lysophosphatidic Acid Receptor Binding
Beta-adrenergic Receptor Kinase Activity
Biological Process
Regulation Of G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of GTPase Activity
Desensitization Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Tachykinin Receptor Signaling Pathway
Heart Development
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Viral Genome Replication
Receptor Internalization
Positive Regulation Of Catecholamine Secretion
Negative Regulation Of Striated Muscle Contraction
Viral Entry Into Host Cell
Cardiac Muscle Contraction
Negative Regulation Of Relaxation Of Smooth Muscle
Pathways
Calmodulin induced events
G alpha (q) signalling events
G alpha (s) signalling events
Activation of SMO
Activation of SMO
Cargo recognition for clathrin-mediated endocytosis
Drugs
ATP
Diseases
GWAS
Bipolar disorder (
31043756
)
Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia (
28922980
)
Metabolic syndrome (
20694148
)
Metabolite levels (
23823483
)
Metabolite levels (MHPG) (
23319000
)
Interacting Genes
48 interacting genes:
ACTG1
ACTN1
ARHGEF6
ARHGEF7
ATF5
C4BPA
CALCOCO2
CDC42
CORO1A
E2F2
EDC4
GCH1
GET4
GIT1
GRK2
GUSB
HGD
HNRNPUL1
IKBKG
KCTD5
KRT18
LAMTOR5
LMNB1
MVP
NFKBIB
NME2
PAK1
PAK3
PCLO
POLR1B
PROX1
PXN
QPRT
RCVRN
RUFY1
RUSC2
SAFB2
SH3GLB2
SMAD3
SPOP
TGFB1I1
TNFAIP3
TNIP1
TRAF1
TSN
UBQLN1
USHBP1
YWHAG
51 interacting genes:
ADRA2A
ADRB2
AGTR1
AKAP12
ARRB1
ARRB2
BDKRB2
CAPN2
CAV1
CCR4
CCR5
CSNK2B
EGF
EGFR
EPHA2
ERBB2
FBXO25
FPR1
FSHR
GIT1
GIT2
GNA15
GNAQ
GNB2
GNB3
GRM1
HDAC6
KCNIP3
MAPK3
MC4R
MDM2
NCS1
OPRD1
PDC
PDCL
PDE6G
PEBP1
PIK3CG
PLCB1
PRKACA
PRKCA
PRKCB
PRKCD
PRKCG
RASGRF1
RCVRN
RHO
RPLP2
SNCA
SRC
TPM2
Entrez ID
9815
156
HPRD ID
09779
00182
Ensembl ID
ENSG00000139436
ENSG00000173020
Uniprot IDs
F8VXI9
F8W822
Q14161
Q68DM7
Q6FI58
A0A0S2Z392
P25098
PDB IDs
1BAK
3CIK
3KRW
3KRX
3V5W
4MK0
4PNK
5HE1
5UKK
5UKL
5UUU
5UVC
5WG3
5WG4
5WG5
6C2Y
6U7C
7K7L
7K7Z
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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