MTA2 and ERCC6

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MTA2	ERCC6
Description		metastasis associated 1 family member 2	ERCC excision repair 6, chromatin remodeling factor
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Transcription Elongation Factor Complex Site Of DNA Damage
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding	DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Protein C-terminus Binding DNA-dependent ATPase Activity Protein Tyrosine Kinase Activator Activity Sequence-specific DNA Binding Protein-containing Complex Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator	Single Strand Break Repair DNA Damage Checkpoint Response To Superoxide Transcription-coupled Nucleotide-excision Repair Base-excision Repair Pyrimidine Dimer Repair Transcription Elongation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Response To Oxidative Stress Activation Of JNKK Activity Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance Response To X-ray Response To UV-B Response To Gamma Radiation Neurogenesis Neuron Differentiation Neuron Projection Development DNA Duplex Unwinding Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Multicellular Organism Growth ATP-dependent Chromatin Remodeling Photoreceptor Cell Maintenance Positive Regulation Of DNA Repair Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Protein Tyrosine Kinase Activity Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression B-WICH complex positively regulates rRNA expression Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER RNA Polymerase I Transcription Initiation
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome Cockayne syndrome Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	118 interacting genes: ACTR2 ACTR3 ARPC1A ATP5F1C ATP5PO BRCA1 CAVIN1 CCT5 CCT6A CHEK2 CLIC4 COPE CORO1C CSNK2A2 CSNK2B CTSB CUL5 DARS1 ECHS1 EIF3C EIF3D EIF3F EIF3I EIF3L EIF4A3 ELOA ERCC5 ERCC8 FBLN2 FNDC3B FOSL1 FXR1 FYTTD1 GATAD2B GRPEL1 GTF2E2 GTF2I H2BC3 H3C1 H4C1 HDAC1 HDAC2 HNRNPUL2 HSPA5 HSPA9 HTATSF1 IARS2 IDH3G IWS1 LEO1 MBD3 MORC3 MRPL11 MRPL13 MRPL20 MRPL21 MRPL3 MRPL38 MRPL4 MRPL47 MRPL50 MRPL58 MRPS18B MRPS22 MRPS25 MRPS26 MTA1 MTA2 MTA3 NAP1L1 NONO NPLOC4 PAF1 PARP1 PCNA PFN2 PML POLR2A POLR2H PPIA PSMC5 RBBP4 RBBP7 RCC1 RHOG RNF11 RPL10 RPL13 RPL30 RPL39 RPL5 RPS15 RPS15A RPS24 RPS29 RPS6 SAE1 SDHA SENP2 SF3B3 SLC39A7 SNRPD1 SUMO1 SUMO2 SUPT6H TACO1 TP53 TPR UBA2 UBC UBE2I UQCRC1 UQCRQ USP7 XAB2 XPA XRCC5 ZBTB38
Entrez ID		9219	2074
HPRD ID		07233	00596
Ensembl ID		ENSG00000149480	ENSG00000225830
Uniprot IDs		A0A024R534 O94776	A8K4Q3 P0DP91 Q03468 Q59FF6
PDB IDs			4CVO 6A6I
Enriched GO Terms of Interacting Partners?
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