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ERCC6 and RPS15
Data Source:
BioGRID
(pull down)
ERCC6
RPS15
Description
ERCC excision repair 6, chromatin remodeling factor
ribosomal protein S15
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Site Of DNA Damage
Nucleus
Nucleoplasm
Cytosol
Focal Adhesion
Membrane
Cytosolic Small Ribosomal Subunit
Molecular Function
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
DNA Binding
RNA Binding
Structural Constituent Of Ribosome
Protein Binding
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint
Response To Superoxide
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Response To Oxidative Stress
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Neurogenesis
Neuron Differentiation
Neuron Projection Development
DNA Duplex Unwinding
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
ATP-dependent Chromatin Remodeling
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Protein Tyrosine Kinase Activity
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Ribosomal Small Subunit Assembly
Ribosomal Small Subunit Export From Nucleus
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Osteoblast Differentiation
RRNA Processing
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Ribosomal Small Subunit Biogenesis
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Cockayne syndrome
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
118 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
BRCA1
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP4
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
11 interacting genes:
CDC42
DUX4
ERCC6
G2E3
NAP1L1
PLA2G12A
PTEN
RAPGEF1
RPS4X
SERINC3
UPF2
Entrez ID
2074
6209
HPRD ID
00596
01613
Ensembl ID
ENSG00000225830
ENSG00000115268
Uniprot IDs
A8K4Q3
P0DP91
Q03468
Q59FF6
K7ELC2
P62841
PDB IDs
4CVO
6A6I
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6FEC
6G18
6G4S
6G4W
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZVH
6ZVJ
7A09
7K5I
Enriched GO Terms of Interacting Partners
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