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ERCC6 and ERCC8
Data Source:
HPRD
(in vitro)
ERCC6
ERCC8
Description
ERCC excision repair 6, chromatin remodeling factor
ERCC excision repair 8, CSA ubiquitin ligase complex subunit
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Site Of DNA Damage
Nucleotide-excision Repair Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Matrix
Cul4A-RING E3 Ubiquitin Ligase Complex
Protein-containing Complex
Perikaryon
Cul4-RING E3 Ubiquitin Ligase Complex
Molecular Function
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
DNA Helicase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
DNA-dependent ATPase Activity
Protein-containing Complex Binding
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint
Response To Superoxide
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Response To Oxidative Stress
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Neurogenesis
Neuron Differentiation
Neuron Projection Development
DNA Duplex Unwinding
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
ATP-dependent Chromatin Remodeling
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Protein Tyrosine Kinase Activity
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Single Strand Break Repair
Protein Polyubiquitination
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Response To UV
Response To X-ray
Response To Auditory Stimulus
Response To Organic Cyclic Compound
DNA Duplex Unwinding
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of DNA Repair
Protein Autoubiquitination
Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Neddylation
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Cockayne syndrome
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Cockayne syndrome
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
118 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
BRCA1
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP4
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
11 interacting genes:
CAMK2D
CBR1
CSNK2B
CUL4A
DDB1
ERCC6
GTF2H2
RBX1
TOP1
UQCRQ
XAB2
Entrez ID
2074
1161
HPRD ID
00596
07523
Ensembl ID
ENSG00000225830
ENSG00000049167
Uniprot IDs
A8K4Q3
P0DP91
Q03468
Q59FF6
A0A0S2Z3L1
B3KPW7
B4DGZ9
Q13216
PDB IDs
4CVO
6A6I
4A11
6FCV
Enriched GO Terms of Interacting Partners
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